Voltage jump analysis of procaine action at frog end-plate
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چکیده
منابع مشابه
Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction.
1. Acetylcholine produced end-plate current (e.p.c.) noise is shown to be the results of statistical fluctuations in the ionic conductance of voltage clamped end-plates of Rana pipiens.2. These e.p.c. fluctuations are characterized by their e.p.c. spectra which conform to a relation predicted from a simple model of end-plate channel gating behaviour.3. The rate constant of channel closing alpha...
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Inhibition of transmitter release by protons (H+) was studied at the frog neuromuscular junction at various extracellular concentrations of calcium ([Ca++]o) and potassium ([K+]o) by recording miniature end-plate potential (MEPP) frequency with the intracellular microelectrode. H+ decreased K+ -stimulated MEPP frequency. A double logarithmic graph of MEPP frequency at 7.5 mM K+ vs. [H+]o yielde...
متن کاملBlock of quantal end-plate currents of mouse muscle by physostigmine and procaine.
of quantal end-plate currents of mouse muscle by physostigmine and procaine. Quantal endplate currents (qEPCs) were recorded from hemidiaphragms of mice by means of a macro-patch-clamp electrode. Excitation was blocked with tetrodotoxin, and quantal release was elicited by depolarizing pulses through the electrode. Physostigmine (Phys) or procaine (Proc) was applied to the recording site by per...
متن کاملThe action of procaine and procaine amide on the heart.
The depressant action of procaine on the heart muscle has been the subject of several clinical and experimental studies (Wiggers and Wegria, 1940; Burstein, 1946; Uhley and Wilburne, 1948; Schaffer et al., 1950). Procaine was found useful in the treatment of cardiac arrhythmias occurring in anesthetized patients during cardiac surgery. However, its usefulness in the management of clinical arrhy...
متن کاملEffects of Cesium Ions on the Frequency of Miniature End Potentials at the Frog Neuromuscular Junction -Plate
The effects of Cs ions on the frequency of miniature end-plate potentials (MEPPs) were. investigated at the frog neuromuscular junction. The frequency of MEPPs increased gradually with time, after a delay, when part of the NaCI in normal Ringer's solution was replaced isotonically with CsCI. The delay was greatly prolonged and the rate of increase in MEPP frequency slowed when a low concentrati...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1977
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1977.sp011858